Article

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

2021-04-09

Abstract excerpt

SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal antibodies may now be less effective. This manuscript demonstrates an approach for preventing clinical sequelae and the spread of SARS-CoV-2 variants. First, we affinity-matured an angiotensin-converting enzyme 2 (ACE2) decoy protein, achievin...

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Literature Corpus work: cee29bab-cce3-51dd-b9f9-a93e37cb9a70
DOI: 10.1101/2021.04.09.439149

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