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Article

Structure and function of an effector domain in antiviral factors and tumor suppressors SAMD9 and SAMD9L.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022

Peng Shuxia, Meng Xiangzhi, Zhang Fushun, Pathak Prabhat Kumar, Chaturvedi Juhi, Coronado Jaime, Morales Marisol, Mao Yuanhui, Qian Shu-Bing, Deng Junpeng, Xiang Yan

Abstract excerpt

SAMD9 and SAMD9L (SAMD9/9L) are antiviral factors and tumor suppressors, playing a critical role in innate immune defense against poxviruses and the development of myeloid tumors. SAMD9/9L mutations with a gain-of-function (GoF) in inhibiting cell growth cause multisystem developmental disorders including many pediatric myelodysplastic syndromes. Predicted to be multidomain proteins with an architecture like that...

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Identifiers

PMID: 35046037
DOI: 10.1073/pnas.2116550119
PMCID: PMC8795524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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