Article
Cognitive composites for genetic frontotemporal dementia: GENFI-Cog.
Alzheimer's research & therapy - 19 Jan 2022
Poos Jackie M, Moore Katrina M, Nicholas Jennifer, Russell Lucy L, Peakman Georgia, Convery Rhian S, Jiskoot Lize C, van der Ende Emma, van den Berg Esther, Papma Janne M, Seelaar Harro, Pijnenburg Yolande A L, Moreno Fermin, Sanchez-Valle Raquel, Borroni Barbara, Laforce Robert, Masellis Mario, Tartaglia Carmela, Graff Caroline, Galimberti Daniela, Rowe James B, Finger Elizabeth, Synofzik Matthis, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Ducharme Simon, Butler Chris, Gerhard Alexander, Levin Johannes, Danek Adrian, Otto Markus, Le Ber Isabel, Pasquier Florence, van Swieten John C, Rohrer Jonathan D
Abstract excerpt
BACKGROUND: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. METHODS: A standardized...
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