Article
Microbiome differential abundance methods produce different results across 38 datasets.
Nature communications - 17 Jan 2022
Nearing Jacob T, Douglas Gavin M, Hayes Molly G, MacDonald Jocelyn, Desai Dhwani K, Allward Nicole, Jones Casey M A, Wright Robyn J, Dhanani Akhilesh S, Comeau André M, Langille Morgan G I
Abstract excerpt
Identifying differentially abundant microbes is a common goal of microbiome studies. Multiple methods are used interchangeably for this purpose in the literature. Yet, there are few large-scale studies systematically exploring the appropriateness of using these tools interchangeably, and the scale and significance of the differences between them. Here, we compare the performance of 14 differential abundance...
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