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Article

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

12 Oct 2018

Abstract excerpt

BACKGROUND: Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic memory loss. MicroRNA (miRNA) deregulation is well established in AD brain but it is unclear whether Aβ or TAU pathology drives those alterations and whether miRNA changes contribute to cognitive decline. METHODS: ) and TAUtg (THY-Tau22) mice and...

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PMID: 30314521
DOI: 10.1186/s13024-018-0285-1

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