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Article

NT5E mutation in sisters who underwent aortic valve replacements for aortic stenosis.

Interactive cardiovascular and thoracic surgery - 6 Jan 2022

Uchida Tetsuro, Yamashita Atsushi, Ishizawa Ai, Sadahiro Mitsuaki, Azuma Nobuyoshi, Kaname Tadashi

Abstract excerpt

Mutations of the NT5E gene encoding the cluster of differentiation 73 (CD73) protein have been found in patients with characteristic calcification of joints and arteries (CALJA). CD73 plays a protective role against aortic valve calcification; therefore, its deletion results in aortic valve calcification. However, to date, there are no reports of a patient with CALJA with aortic stenosis. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34999808
DOI: 10.1093/icvts/ivab229
PMCID: PMC8932508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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