Article
Occult Transthyretin Cardiac Amyloid in Severe Calcific Aortic Stenosis: Prevalence and Prognosis in Patients Undergoing Surgical Aortic Valve Replacement.
Circulation. Cardiovascular imaging - 1 Aug 2016
Treibel Thomas A, Fontana Marianna, Gilbertson Janet A, Castelletti Silvia, White Steven K, Scully Paul R, Roberts Neil, Hutt David F, Rowczenio Dorota M, Whelan Carol J, Ashworth Michael A, Gillmore Julian D, Hawkins Philip N, Moon James C
Abstract excerpt
BACKGROUND: Calcific aortic stenosis (cAS) affects 3% of individuals aged >75 years, leading to heart failure and death unless the valve is replaced. Wild-type transthyretin cardiac amyloid is also a disorder of ageing individuals. Prevalence and clinical significance of dual pathology are unknown. This study explored the prevalence of wild-type transthyretin amyloid in cAS by myocardial biopsy, its imaging...
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