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Article

Gut dysbiosis is associated with acceleration of lupus nephritis.

Scientific reports - 7 Jan 2022

Valiente Giancarlo R, Munir Armin, Hart Marcia L, Blough Perry, Wada Takuma T, Dalan Emma E, Willis William L, Wu Lai-Chu, Freud Aharon G, Jarjour Wael N

Abstract excerpt

The gut microbiota (GM) exerts a strong influence over the host immune system and dysbiosis of this microbial community can affect the clinical phenotype in chronic inflammatory conditions. To explore the role of the GM in lupus nephritis, we colonized NZM2410 mice with Segmented Filamentous Bacteria (SFB). Gut colonization with SFB was associated with worsening glomerulonephritis, glomerular and tubular immune...

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Identifiers

PMID: 34996983
DOI: 10.1038/s41598-021-03886-5
PMCID: PMC8742035

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