Article
One-carbon metabolism pathway genes and their non-association with the development of amyotrophic lateral sclerosis.
Journal of cellular biochemistry - 1 Mar 2022
de Lima Nayane S, da Costa Caroline C P, Assunção Leandro do P, Santos Kamilla de F, Bento Dhiogo da C P, da Silva Reis Angela A, Santos Rodrigo da S
Abstract excerpt
Although of unknown etiology, some mechanisms associated with the metabolic cycle of folate are speculated to be related to the genesis of amyotrophic lateral sclerosis (ALS). Thus, the aim of the study was to analyze the role of genetic polymorphisms rs1051266 in SLC19A1 gene and rs1805087 in MTR gene and their associations with ALS development. A case-control study was conducted with 101 individuals with ALS...
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