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Article

4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts.

JCI insight - 8 Feb 2022

Scheiber Amanda L, Wilkinson Kevin J, Suzuki Akiko, Enomoto-Iwamoto Motomi, Kaito Takashi, Cheah Kathryn Se, Iwamoto Masahiro, Leikin Sergey, Otsuru Satoru

Abstract excerpt

Short stature is a major skeletal phenotype in osteogenesis imperfecta (OI), a genetic disorder mainly caused by mutations in genes encoding type I collagen. However, the underlying mechanism is poorly understood, and no effective treatment is available. In OI mice that carry a G610C mutation in COL1A2, we previously found that mature hypertrophic chondrocytes (HCs) are exposed to cell stress due to accumulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34990412
DOI: 10.1172/jci.insight.149636
PMCID: PMC8855815

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