Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts.

The Journal of biological chemistry - 1 Jan 2000

Takeyari Shinji, Kubota Takuo, Ohata Yasuhisa, Fujiwara Makoto, Kitaoka Taichi, Taga Yuki, Mizuno Kazunori, Ozono Keiichi

Abstract excerpt

Osteogenesis imperfecta (OI) is a heritable brittle bone disease mainly caused by mutations in the two type I collagen genes. Collagen synthesis is a complex process including trimer formation, glycosylation, secretion, extracellular matrix (ECM) formation, and mineralization. Using OI patient-derived fibroblasts and induced pluripotent stem cells (iPSCs), we investigated the effect of 4-phenylbutyric acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcification, Physiologic
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Induced Pluripotent Stem Cells

Share to Osteoblasts

Share to Osteogenesis Imperfecta

Share to Phenylbutyrates

Share to Protein Folding

Source

Open in PubMed Open full text

Identifiers

PMID: 33154166
DOI: 10.1074/jbc.RA120.014709
PMCID: PMC7948972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts.PMID 33154166Read ↗

Targeting cellular stress in vitro improves osteoblast homeostasis, matrix collagen content and mineralization in two murine models of osteogenesis imperfecta.Semantic proximity Read ↗

4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion.Semantic proximity Read ↗

4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts.Semantic proximity Read ↗

Osteogenesis imperfecta and therapeutics.Semantic proximity Read ↗

Osteogenesis imperfecta.Semantic proximity Read ↗

Osteogenesis Imperfecta: Current and Prospective Therapies.Semantic proximity Read ↗

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.Semantic proximity Read ↗

Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.Semantic proximity Read ↗

Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta.Semantic proximity Read ↗

Osteogenesis imperfecta: prospects for molecular therapeutics.Semantic proximity Read ↗

Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCsSemantic proximity Read ↗

Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.