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Article

Genetic analysis of a malignant meningioma and associated metastases.

Acta neurochirurgica - 1 May 2022

Huntoon Kristin, Yilmaz Ayse Selen, Pietrzak Maciej, Chen Xi, Yan Pearlly, Toland Amanda Ewart, Elder J Bradley

Abstract excerpt

To identify genes altered in a highly aggressive metastatic meningioma primary as well as its metastases. Exome sequencing of a primary anaplastic meningioma and metastatic lesions in which DNA could be extracted and compared to germline DNA. Genetic analysis of the metastatic sites found 31 common mutations among the primary tumor and two metastatic sites. Additionally, genetic mutations were identified which...

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PMID: 34981192
DOI: 10.1007/s00701-021-05101-w

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