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Article

Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.

International journal of molecular sciences - 31 Aug 2022

Katsuta Eriko, Takabe Kazuaki, Vujcic Marija, Gottlieb Philip A, Dai Tao, Mercado-Perez Arnaldo, Beyder Arthur, Wang Qingfei, Opyrchal Mateusz

Abstract excerpt

BACKGROUND: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca2+ channels, and cell depolarization. This study aimed to investigate PIEZO2's role in breast cancer. METHODS: The clinical relevance of PIEZO2 expression in breast cancer patient was analyzed in a publicly available dataset. Utilizing PIEZO2 overexpressed breast cancer cells, and in vitro and in vivo...

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Identifiers

PMID: 36077309
DOI: 10.3390/ijms23179909
PMCID: PMC9455988

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Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.PMID 36077309Read ↗

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