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Role of ESAT-6 in pathogenicity of Beijing and non-Beijing Mycobacterium tuberculosis isolates.

Microbial pathogenesis - 1 Jan 2022

Mahghani Ghorban Ali, Kargar Mohammad, Ghaemi Ezzat Allah, Kafilzadeh Farshid, Davoodi Homa

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis Beijing genotype was associated with tuberculosis outbreaks and increased transmissibility. To understand the variation in virulence between Beijing and non-Beijing clinical isolates of M.tuberculosis genotypes, the esat-6 gene sequencing, and its expression was compared in the macrophage environment. MATERIALS & METHODS: Among 64 nonrepetitive, culture-positive...

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PMID: 34968645
DOI: 10.1016/j.micpath.2021.105366

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