Article
Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Feb 2022
Lam Daniel D, Williams Rhîannan H, Lujan Ernesto, Tanabe Koji, Huber Georg, Saw Nay Lui, Merl-Pham Juliane, Salminen Aaro V, Lohse David, Spendiff Sally, Plastini Melanie J, Zech Michael, Lochmüller Hanns, Geerlof Arie, Hauck Stefanie M, Shamloo Mehrdad, Wernig Marius, Winkelmann Juliane
Abstract excerpt
Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing the movement disorder dystonia. To elucidate the neurophysiological role of collagen VI, we generated mice with a truncation of the dystonia-related collagen α3 VI...
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