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Article

The Roles of the Dystrophin-Associated Glycoprotein Complex at the Synapse

8 Nov 2009

Abstract excerpt

Duchenne muscular dystrophy is caused by mutations in the dystrophin gene and is characterized by progressive muscle wasting. A number of Duchenne patients also present with mental retardation. The dystrophin protein is part of the highly conserved dystrophin-associated glycoprotein complex (DGC) which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central...

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PMID: 19899002
DOI: 10.1007/s12035-009-8089-5

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