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Article

β-Carotene Oxygenase 2 Genotype Modulates the Impact of Dietary Lycopene on Gene Expression during Early TRAMP Prostate Carcinogenesis.

The Journal of nutrition - 1 Apr 2022

Moran Nancy E, Thomas-Ahner Jennifer M, Smith Joshua W, Silva Ceasar, Hason Noor A, Erdman John W, Clinton Steven K

Abstract excerpt

BACKGROUND: Epidemiologic studies suggest lycopene and tomato intake are inversely associated with human prostate cancer incidence. In the genetically driven murine prostate carcinogenesis model transgenic adenocarcinoma of the mouse prostate (TRAMP), prostate cancer is inhibited by feeding of lycopene or tomatoes, and these effects are modulated by the β-carotene oxygenase 2 (Bco2) genotype. OBJECTIVE: We sought...

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Identifiers

PMID: 34964896
DOI: 10.1093/jn/nxab445
PMCID: PMC8971008

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