Article
Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis.
Scientific reports - 8 Dec 2021
Rahbar Mohammad Reza, Jahangiri Abolfazl, Khalili Saeed, Zarei Mahboubeh, Mehrabani-Zeinabad Kamran, Khalesi Bahman, Pourzardosht Navid, Hessami Anahita, Nezafat Navid, Sadraei Saman, Negahdaripour Manica
Abstract excerpt
Spike glycoprotein (Sgp) is liable for binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the host receptors. Since Sgp is the main target for vaccine and drug designing, elucidating its mutation pattern could help in this regard. This study is aimed at investigating the correspondence of specific residues to the SgpSARS-CoV-2 functionality by explorative interpretation of sequence...
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