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Article

PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells.

Scientific reports - 3 Jul 2017

Kaku Yusuke, Taguchi Atsuhiro, Tanigawa Shunsuke, Haque Fahim, Sakuma Tetsushi, Yamamoto Takashi, Nishinakamura Ryuichi

Abstract excerpt

The kidney is formed by reciprocal interactions between the nephron progenitor and the ureteric bud, the former of which gives rise to the epithelia of nephrons consisting of glomeruli and renal tubules. The transcription factor PAX2 is essential for this mesenchymal-to-epithelial transition of nephron progenitors, as well as ureteric bud lineage development, in mice. PAX2 mutations in humans cause renal coloboma...

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Source

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Identifiers

PMID: 28674456
DOI: 10.1038/s41598-017-04813-3
PMCID: PMC5495778

Genes

PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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