Article
Multiplex SNP Genotyping Using SWITCH: Sequence-Specific Nanoparticle with Interpretative Toehold-Mediated Sequence Decoding in Hydrogel.
Small (Weinheim an der Bergstrasse, Germany) - 1 Feb 2022
Choi Woongsun, Park Eunhye, Bae Seojin, Choi Kyung-Hak, Han Sangeun, Son Kuk-Hui, Lee Do Young, Cho Il-Joo, Seong Hyejeong, Hwang Kyo Seon, Nam Jwa-Min, Choi Jungkyu, Lee Hyojin, Choi Nakwon
Abstract excerpt
Single nucleotide polymorphisms (SNPs) that can alter phenotypes of individuals play a pivotal role in disease development and, more importantly, responses to therapy. However, SNP genotyping has been challenging due to the similarity of SNP alleles and their low concentration in biological samples. Sequence-specific nanoparticle with interpretative toehold-mediated sequence decoding in hydrogel (SWITCH) for...
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