Emergence of dalbavancin non-susceptible methicillin-resistant Staphylococcus epidermidis (MRSE) in a patient treated with dalbavancin prolonged therapy: Case report, therapeutic drug monitoring and genomic characterization.

Abstract excerpt

OBJECTIVE: We reported stepwise evolution of a Methicillin-Resistant Staphylococcus epidermidis (MRSE) with reduced susceptibility to dalbavancin in a patient with recurrent episode of bloodstream infections (BSIs). METHODS: SNPs (single nucleotide polymorphism) and insert/deletions analysis between genomes of dalbavancin -susceptible and -non-susceptible strains was performed. Dalbavancin exposure and PK/PD...

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• Anti-Bacterial Agents
• Bacteremia
• DNA-Directed RNA Polymerases
• Methicillin Resistance