Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype.

doi:10.1093/sleep/zsab290

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Article

Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype.

Sleep - 13 Jun 2022

Zhen Xin, Moya Esteban A, Gautane Mary, Zhao Huayi, Lawrence Elijah S, Gu Wanjun, Barnes Laura A, Yuan Jason X-J, Jain Pritesh P, Xiong Mingmei, Catalan Serra Pablo, Pham Luu V, Malhotra Atul, Simonson Tatum S, Mesarwi Omar A

Abstract excerpt

STUDY OBJECTIVES: Chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome is associated with excess mortality, and outcomes are related to the degree of hypoxemia. People at high altitudes are susceptible to periodic breathing, and hypoxia at altitude is associated with cardio-metabolic dysfunction. Hypoxemia in these scenarios may be described as superimposed sustained hypoxia (SH)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34893914
DOI: 10.1093/sleep/zsab290
PMCID: PMC9189937

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