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Article

Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea

8 Jun 2017

Abstract excerpt

Abstract Intermittent hypoxia (IH) induces activation of the integrated stress response (ISR), but its role in IH-induced visceral white adipose tissue (vWAT) insulin resistance is unknown. CHOP is activated by chronic ISR, whereas GADD34 dephosphorylates the subunit of translation initiation factor 2 (eIF2α), leading to termination of the ISR. We hypothesized that CHOP/Gadd34 null mice would not manifest...

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PMID: 28594573
DOI: 10.1165/rcmb.2017-0057oc

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