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Article

Glitazone Treatment Rescues Phenotypic Deficits in a Fly Model of Gaucher/Parkinson's Disease.

International journal of molecular sciences - 25 Nov 2021

Shola-Dare Oluwanifemi, Bailess Shelby, Flores Carlos C, Vanderheyden William M, Gerstner Jason R

Abstract excerpt

Parkinson's Disease (PD) is the most common movement disorder, and the strongest genetic risk factor for PD is mutations in the glucocerebrosidase gene (GBA). Mutations in GBA also lead to the development of Gaucher Disease (GD), the most common type of lysosomal storage disorder. Current therapeutic approaches fail to address neurological GD symptoms. Therefore, identifying therapeutic strategies that improve...

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Identifiers

PMID: 34884544
DOI: 10.3390/ijms222312740
PMCID: PMC8657993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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