Article
GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jan 2022
Larbalestier Hannah, Keatinge Marcus, Watson Lisa, White Emma, Gowda Siri, Wei Wenbin, Koler Katjusa, Semenova Svetlana A, Elkin Adam M, Rimmer Neal, Sweeney Sean T, Mazzolini Julie, Sieger Dirk, Hide Winston, McDearmid Jonathan, Panula Pertti, MacDonald Ryan B, Bandmann Oliver
Abstract excerpt
The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in tetrahydrobiopterin (BH4) synthesis, an essential cofactor in the synthesis of monoaminergic neurotransmitters. To investigate the mechanisms by which GCH1 deficiency may contribute to PD, we generated a loss of function zebrafish gch1 mutant (gch1-/-), using CRISPR/Cas technology. gch1-/- zebrafish develop...
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