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Article

Decomposition of cell activities revealing the role of the cell cycle in driving biofunctional heterogeneity.

Scientific reports - 6 Dec 2021

Lan Tian, Yu Meng, Chen Weisheng, Yin Jun, Chang Hsiang-Tsun, Tang Shan, Zhao Ye, Svoronos Spyros, Wong Samuel W K, Tseng Yiider

Abstract excerpt

Heterogeneity of cell phenotypes remains a barrier in progressing cell research and a challenge in conquering cancer-related drug resistance. Cell morphology, the most direct property of cell phenotype, evolves along the progression of the cell cycle; meanwhile, cell motility, the dynamic property of cell phenotype, also alters over the cell cycle. However, a quantifiable research understanding the relationship...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34873244
DOI: 10.1038/s41598-021-02926-4
PMCID: PMC8648726

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