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The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells

6 Dec 2021

Abstract excerpt

Paclitaxel is an anti-microtubule agent that has been shown to induce cell death in gastric cancer. However, the detailed mechanism of action is unclear. In this study, we reveal that the paclitaxel-induced cell death mechanism involves mitotic catastrophe, autophagy and apoptosis in AGS cells. Paclitaxel induced intrinsic apoptosis by activating caspase-3, caspase-9 and PARP. In addition, the significant...

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PMID: 34873207
DOI: 10.1038/s41598-021-02503-9

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