Article
Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53.
Molecules (Basel, Switzerland) - 15 Mar 2021
Long Solida, Loureiro Joana B, Carvalho Carla, Gales Luís, Saraiva Lucília, Pinto Madalena M M, Puthongking Ploenthip, Sousa Emília
Abstract excerpt
The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline (1),...
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