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Article

Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53.

Chemical research in toxicology - 19 Sept 2022

Sadahiro Yusaku, Hitora Yuki, Kimura Ichiro, Hitora-Imamura Natsuko, Onodera Risako, Motoyama Keiichi, Tsukamoto Sachiko

Abstract excerpt

Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A2 (CF) from the fungus Colletotrichum sp. (13S020), which decreases mutant p53 levels in cells, and herein examine its effect on mutant p53. CF showed more potent...

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PMID: 36027604
DOI: 10.1021/acs.chemrestox.2c00202

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