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Article

Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 24 Mar 2022

Katsuhara Shunsuke, Yokomoto-Umakoshi Maki, Umakoshi Hironobu, Matsuda Yayoi, Iwahashi Norifusa, Kaneko Hiroki, Ogata Masatoshi, Fukumoto Tazuru, Terada Eriko, Sakamoto Ryuichi, Ogawa Yoshihiro

Abstract excerpt

CONTEXT: Prolonged exposure to pathological cortisol, as in Cushing's syndrome causes various age-related disorders, including sarcopenia. However, it is unclear whether mild cortisol excess, for example, accelerates sarcopenia due to aging or chronic stress. OBJECTIVE: We used Mendelian randomization (MR) analysis to assess whether cortisol was causally associated with muscle strength and mass. METHODS: Three...

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PMID: 34850018
DOI: 10.1210/clinem/dgab862

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