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Article

Searching for multiple folding pathways of a nearly symmetrical protein: temperature dependent phi-value analysis of the B domain of protein A.

Journal of molecular biology - 7 Sept 2007

Sato Satoshi, Fersht Alan R

Abstract excerpt

The B domain of protein A (BdpA) is a popular paradigm for simulating protein folding pathways. The discrepancies between so many simulations and subsequent experimental testing may be attributable to the protein being highly symmetrical: changing experimental conditions could perturb the subtle interplay between the effects of symmetry in the native structure and the effects of asymmetry from specific...

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Identifiers

PMID: 17628591
DOI: 10.1016/j.jmb.2007.06.043

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