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Article

Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring

10 Sept 2024

Abstract excerpt

Emerging studies suggest that various parental exposures affect offspring cardiovascular health, yet the specific mechanisms, particularly the influence of paternal cardiovascular disease (CVD) risk factors on offspring cardiovascular health, remain elusive. The present study explores how paternal hypercholesterolemia affects offspring atherosclerosis development using the LDL receptor-deficient (LDLR-/-) mouse...

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PMID: 39253968
DOI: 10.1172/jci.insight.179291

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