Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis

1 Nov 2021

Abstract excerpt

Coiled-coil domain containing 6 (CCDC6) is a tumour suppressor gene involved in apoptosis and DNA damage response. CCDC6 is known to be functionally impaired upon gene fusions, somatic mutations, and altered protein turnover in several tumours. Testicular germ cell tumours are among the most common malignancies in young males. Despite the high cure rate, achieved through chemotherapy and/or surgery, drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34841108
DOI: 10.1016/j.heliyon.2021.e08399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosisPMID 34841108Read ↗

Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice.Semantic proximity Read ↗

CCDC6: the identity of a protein known to be partner in fusion.Semantic proximity Read ↗

Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumorsSemantic proximity Read ↗

KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis EvasionSemantic proximity Read ↗

KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion.Semantic proximity Read ↗

Ccdc87 is critical for sperm function and male fertility†Semantic proximity Read ↗

A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in MiceSemantic proximity Read ↗

The disruption of the CCDC6 - PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma.Semantic proximity Read ↗

The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis‐inducing stimuliSemantic proximity Read ↗

Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein.Semantic proximity Read ↗

Tumor-Associated Antigen xCT and Mutant-p53 as Molecular Targets for New Combinatorial Antitumor Strategies.Semantic proximity Read ↗

Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.