Article
Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients.
Clinical and molecular hepatology - 1 Apr 2022
Liu Wen-Yue, Zhang Xiaofang, Li Gang, Tang Liang-Jie, Zhu Pei-Wu, Rios Rafael S, Zheng Kenneth I, Ma Hong-Lei, Wang Xiao-Dong, Pan Qiuwei, de Knegt Robert J, Valenti Luca, Ghanbari Mohsen, Zheng Ming-Hua
Abstract excerpt
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL) gene in human, has been implicated in the pathogenesis of metabolic dysfunctions. However, the impact of variants in KL on NAFLD risk remains poorly understood. The aim of this study was...
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