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Genetic factors affecting dopaminergic deterioration during the premotor stage of Parkinson disease

26 Nov 2021

Abstract excerpt

To estimate dopaminergic dysfunction in patients with Parkinson disease (PD) during the premotor stage and to investigate the effect of genetic factors on the trajectories. Using longitudinal dopamine transporter single-photon emission computed tomography data from 367 sporadic PD (sPD), 72 LRRK2 (G2019S), and 39 GBA (N370S) PD patients in the Parkinson's Progression Markers Initiative (PPMI) study, we estimated...

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PMID: 34836969
DOI: 10.1038/s41531-021-00250-2

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