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Article

Intratumoral Heterogeneity Promotes Collective Cancer Invasion through NOTCH1 Variation.

Cells - 9 Nov 2021

Torab Peter, Yan Yue, Ahmed Mona, Yamashita Hironobu, Warrick Joshua I, Raman Jay D, DeGraff David J, Wong Pak Kin

Abstract excerpt

Cellular and molecular heterogeneity within tumors has long been associated with the progression of cancer to an aggressive phenotype and a poor prognosis. However, how such intratumoral heterogeneity contributes to the invasiveness of cancer is largely unknown. Here, using a tumor bioengineering approach, we investigate the interaction between molecular subtypes within bladder microtumors and the corresponding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34831307
DOI: 10.3390/cells10113084
PMCID: PMC8619970

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