Article
KRAS A146 Mutations Are Associated With Distinct Clinical Behavior in Patients With Colorectal Liver Metastases.
JCO precision oncology - 1 Jan 2021
van 't Erve Iris, Wesdorp Nina J, Medina Jamie E, Ferreira Leonardo, Leal Alessandro, Huiskens Joost, Bolhuis Karen, van Waesberghe Jan-Hein T M, Swijnenburg Rutger-Jan, van den Broek Daan, Velculescu Victor E, Kazemier Geert, Punt Cornelis J A, Meijer Gerrit A, Fijneman Remond J A
Abstract excerpt
Somatic KRAS mutations occur in approximately half of the patients with metastatic colorectal cancer (mCRC). Biologic tumor characteristics differ on the basis of the KRAS mutation variant. KRAS mutations are known to influence patient prognosis and are used as predictive biomarker for treatment decisions. This study examined clinical features of patients with mCRC with a somatic mutation in KRAS G12, G13, Q61,...
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