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The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant

15 Aug 2023

Abstract excerpt

Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated with moyamoya disease, a rare cerebrovascular disease. It is located in the cytosol and perinuclear space. Missense mutations in this gene have been found to be more prevalent in patients with moyamoya disease compared with that in healthy individuals. Understanding the molecular function of...

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PMID: 37655297
DOI: 10.3389/fcimb.2023.1205355

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