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Article

O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.

PloS one - 1 Jan 2021

Suthakaran Nirthieca, Wiggins Jonathan, Giles Andrew, Opperman Karla J, Grill Brock, Dawson-Scully Ken

Abstract excerpt

Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function. C. elegans possess conserved nervous system features such as gamma-aminobutyric...

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PMID: 34797853
DOI: 10.1371/journal.pone.0260072
PMCID: PMC8604358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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