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Article

Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2022

Kee Zizheng, Ong Sze Min, Heng Chew-Kiat, Ooi Delicia Shu Qin

Abstract excerpt

The first genome-wide association study on coronary artery disease (CAD) in the Han Chinese population identified C6orf105 as a susceptibility gene. The C6orf105 gene was later found to encode for a protein that regulates tissue factor pathway inhibitor (TFPI) expression in endothelial cells in an androgen-dependent manner, and the novel protein was thus termed androgen-dependent TFPI-regulating protein (ADTRP)....

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PMID: 34797389
DOI: 10.1007/s00109-021-02160-5

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