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Article

Insulin signaling and osmotic stress response regulate arousal and developmental progression of C. elegans at hatching.

Genetics - 4 Jan 2022

Bayer Emily A, Liberatore Katarina M, Schneider Jordan R, Schlesinger Evan, He Zhengying, Birnbaum Susanna, Wightman Bruce

Abstract excerpt

The progression of animal development from embryonic to juvenile life depends on the coordination of organism-wide responses with environmental conditions. We found that two transcription factors that function in interneuron differentiation in Caenorhabditis elegans, fax-1, and unc-42, are required for arousal and progression from embryogenesis to larval life by potentiating insulin signaling. The combination of...

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Identifiers

PMID: 34788806
DOI: 10.1093/genetics/iyab202
PMCID: PMC8733457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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