Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development

1 Nov 2021

Abstract excerpt

CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this study, Cnot6/6l double knockout mice are generated. Cnot6l −/− female mice are infertile, with poor ovarian responses to gonadotropins. Follicle-stimulating hormone (FSH)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Reproductive Biology and Fertility
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34788619
DOI: 10.1016/j.celrep.2021.110007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle developmentPMID 34788619Read ↗

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complexSemantic proximity Read ↗

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell ProliferationSemantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

Regulation of autophagic response by CNOT11 via IL-6/JAK/STAT signalingSemantic proximity Read ↗

Biallelic Recessive Mutations in TLE6 and NLRP5 Cause Female Infertility Characterized by Human Early Embryonic ArrestSemantic proximity Read ↗

Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytesSemantic proximity Read ↗

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertilitySemantic proximity Read ↗

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearanceSemantic proximity Read ↗

Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.Semantic proximity Read ↗

Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism.Semantic proximity Read ↗

DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in MiceSemantic proximity Read ↗

Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by CDS composition and mRNA localisationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.