Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.

doi:10.1186/s13073-021-00991-y

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Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.

Genome medicine - 17 Nov 2021

Charalampous Themoula, Alcolea-Medina Adela, Snell Luke B, Williams Tom G S, Batra Rahul, Alder Christopher, Telatin Andrea, Camporota Luigi, Meadows Christopher I S, Wyncoll Duncan, Barrett Nicholas A, Hemsley Carolyn J, Bryan Lisa, Newsholme William, Boyd Sara E, Green Anna, Mahadeva Ula, Patel Amita, Cliff Penelope R, Page Andrew J, O'Grady Justin, Edgeworth Jonathan D

Abstract excerpt

BACKGROUND: Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to improve antimicrobial treatment and infection control decisions. The SARS-CoV-2 pandemic provides added impetus to realise these benefits, given the increased risk of secondary infection and nosocomial transmission of multi-drug-resistant (MDR) pathogens linked with the expansion of critical...

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PMID: 34784976
DOI: 10.1186/s13073-021-00991-y
PMCID: PMC8594956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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