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APC and TP53 Mutations Predict Cetuximab Sensitivity across Consensus Molecular Subtypes

27 Oct 2021

Abstract excerpt

Recently, it was suggested that consensus molecular subtyping (CMS) may aide in predicting response to EGFR inhibitor (cetuximab) therapies. We recently identified that APC and TP53 as two tumor suppressor genes, when mutated, may enhance cetuximab sensitivity and may represent easily measured biomarkers in tumors or blood. Our study aimed to use APC and TP53 mutations (AP) to refine the CMS classification to...

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PMID: 34771559
DOI: 10.3390/cancers13215394

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