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A modified protein marker panel to identify four consensus molecular subtypes in colorectal cancer using immunohistochemistry

7 Mar 2021

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease with different genetic and molecular backgrounds, leading to a diverse patient prognosis and treatment response. Four consensus molecular subtypes (CMS 1–4) have recently been proposed based on transcriptome profiling. A clinically practical immunohistochemistry (IHC) based CMS classifier consisting of the four markers FRMD6, ZEB1 , HTR2B, and CDX2 was then...

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PMID: 33721619
DOI: 10.1016/j.prp.2021.153379

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