Article
Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome.
Stem cell research - 1 Jan 2017
Guo Dongsheng, Wu Feima, Liu Haikun, Gao Ge, Kou Shanglong, Yang Fan, Abbas Nasir, Zhou Tiancheng, Cai Xiujuan, Zhang Hui, Qin Dajiang, Li Jialiang, Xu Kecheng, Li Yin-Xiong
Abstract excerpt
Urine resource cells were collected from a 59-year-old female patient with multiple endocrine neoplasia type 1 syndrome (MEN1) for generating iPS cells with episomal plasmids carrying Oct4, Sox2, Klf4 and miR-302-367. The patient sustained a heterozygous G>T transition mutation on the exon 9 of Men1 gene that was confirmed by sequencing analysis on the obtained iPSC lines. Karyotyping indicated the chromosomes...
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