Transcriptional landscape of a RETC634Y-mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers.

doi:10.1016/j.scr.2017.11.015

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Transcriptional landscape of a RETC634Y-mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers.

Stem cell research - 1 Jan 2018

Hadoux Julien, Desterke Christophe, Féraud Olivier, Guibert Mathieu, De Rose Roberta Francesca, Opolon Paule, Divers Dominique, Gobbo Emilie, Griscelli Frank, Schlumberger Martin, Bennaceur-Griscelli Annelise, Turhan Ali G

Abstract excerpt

MEN2A is a hereditary cancer-predisposing syndrome that affects patients with germline RET mutations. The effects of this oncogenic tyrosine kinase in the context of primitive stem cells are not known. In order to study these events, we generated a MEN2A induced Pluripotent Stem Cell (iPSC) line from a patient with RET mutation and an isogenic counterpart by CRISPR-Cas9 correction of the mutation. Whole exome...

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PMID: 29197744
DOI: 10.1016/j.scr.2017.11.015

Genes

RET
EGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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