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Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

11 Nov 2021

Abstract excerpt

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis process and may be induced by accumulated DNA damage due to local dietary habits. We observe diverse correlations between...

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PMID: 34764264
DOI: 10.1038/s41467-021-26745-3

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