Article
Structure-Based Primer Design Minimizes the Risk of PCR Failure Caused by SARS-CoV-2 Mutations.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Dong Hongjie, Wang Shuai, Zhang Junmei, Zhang Kundi, Zhang Fengyu, Wang Hongwei, Xie Shiling, Hu Wei, Gu Lichuan
Abstract excerpt
The coronavirus disease 2019 (COVID-19) has caused and is still causing tremendous damage to the global economy and human health. Qualitative reverse transcription-PCR (RT-qPCR) is the golden standard for COVID-19 test. However, the SARS-CoV-2 variants may not only make vaccine less effective but also evade RT-qPCR test. Here we suggest an innovative primer design strategy for the RT-qPCR test of SARS-CoV-2. The...
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