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Article

An inherited sudden cardiac arrest syndrome may be based on primary myocardial and autonomic nervous system abnormalities.

Heart rhythm - 1 Feb 2022

Verberne Hein J, Blom Marieke T, Bardai Abdenasser, Karemaker John M, Tan Hanno L

Abstract excerpt

BACKGROUND: A recently discovered sudden cardiac arrest (SCA) syndrome is linked to a risk haplotype that harbors the dipeptidyl-peptidase 6 (DPP6) gene as a plausible culprit. OBJECTIVE: Because DPP6 impacts both cardiomyocyte and neuronal function, we hypothesized that ventricular fibrillation (VF) in risk haplotype carriers arises from functional changes in both the heart and autonomic nervous system. METHODS:...

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Share to Autonomic Nervous System
Share to Death, Sudden, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Source

Identifiers

PMID: 34757187
DOI: 10.1016/j.hrthm.2021.10.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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